loss of heterozygosity

Preferred Label : loss of heterozygosity;

MeSH definition : The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.;

MeSH synonym : heterozygosity, loss of; allelic loss; heterozygosity loss; allelic losses;

CISMeF synonym : loh;

MeSH annotation : do not confuse entry term ALLELIC LOSS with ALLELIC IMBALANCE;

Wikipedia link : https://en.wikipedia.org/wiki/Loss of heterozygosity;

Details

Origin ID

D019656;

UMLS CUI

C0524869;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Loss of Heterozygosity Analysis [NCIt concept]
Currated CISMeF NLP mapping
- Loss of Heterozygosity [NCIt concept]
Record concept(s)
- loss of heterozygosity [MeSH concept]
See also
- hemizygote [MeSH Descriptor]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- Loss of Heterozygosity [NCIt concept]

Keyword's position in hierarchy(ies) :

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