Interferon-Induced Transmembrane Protein 2

Preferred Label : Interferon-Induced Transmembrane Protein 2;

NCIt synonyms : IFITM2; Dispanin Subfamily A Member 2c; DSPA2c; Interferon Induced Transmembrane Protein 2; Interferon-Inducible Protein 1-8D; 1-8D;

NCIt definition : Interferon-induced transmembrane protein 2 (132 aa, 15 kDa) is encoded by the human IFITM2 gene. This protein is involved in cell cycle arrest, caspase-dependent apoptosis and antiviral responses.;

NCIt note : Interferon-induced transmembrane protein 2 permits viral endocytosis but inhibits viral fusion and release of viral contents into the cytosol. Affected viruses include influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). (UniProt);

Details

Origin ID

C179880;

UMLS CUI

C0657731;

Automatic exact mappings (from CISMeF team)
- Interferon-induced transmembrane protein 2 [OMIM gene]
- interferon induced transmembrane protein 2 [HGNC gene]
OMIM relation
- Interferon-induced transmembrane protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IFITM2 protein, human [MeSH Supplementary Concept]
- IFITM2 protein, human [MeSH concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- IFITM2 Gene [NCIt concept]
- Immunoprotein Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- Immune System Process [NCIt concept]
- Interferon Signaling Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Virus-Induced Membrane Fusion [NCIt concept]

Keyword's position in hierarchy(ies) :

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