Transmembrane Protease Serine 4

Preferred Label : Transmembrane Protease Serine 4;

NCIt synonyms : Channel-Activating Protease 2; MT-SP2; EC 3.4.21.-; TMPRSS4; Membrane-Type Serine Protease 2; CAPH2; Channel-Activating Serine Protease 2; Transmembrane Serine Protease 4;

NCIt definition : Transmembrane protease serine 4 (437 aa, 48 kDa) is encoded by the human TMPRSS4 gene. This protein is involved in serine endopeptidase cleavage of target proteins.;

NCIt note : Transmembrane protease serine 4 may facilitate human coronavirus SARS-CoV-2 infection through the cleavage of coronavirus spike glycoproteins. (UniProt);

Details

Origin ID

C179834;

UMLS CUI

C2353720;

Automatic exact mappings (from CISMeF team)
- Non-smc condensin II complex subunit h2 [OMIM gene]
- Transmembrane protease, serine 4 [OMIM gene]
- transmembrane serine protease 4 [HGNC gene]
- transmembrane serine protease 4 [ORDO Gene]
OMIM relation
- Hepsin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TMPRSS4 protein, human [MeSH Supplementary Concept]
- TMPRSS4 protein, human [MeSH concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- TMPRSS4 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Scavenger Receptor Cysteine-Rich Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Ion Transport Process [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients