Preferred Label : JAK2 Inhibitor BS HH 002.SA;
NCIt definition : A derivative of the cytotoxic plant alkaloid homoharringtonine (HHT) and an inhibitor
of Janus-associated kinase 2 (JAK2), with potential antineoplastic activity. Upon
administration, JAK2 inhibitor BS HH 002.SA inhibits JAK2 activity, thereby preventing
the activation of the JAK/signal transducer and activator of transcription (STAT)
signaling pathway and the activation of STAT3 and STAT5. This may lead to an induction
of tumor cell apoptosis and a decrease in tumor cell proliferation. JAK2, often upregulated
or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key
role in tumor cell proliferation and survival.;
Molecule name : BS-HH-002.SA; HH-002; BS HH 002.SA;
NCI Metathesaurus CUI : CL1662430;
Origin ID : C179652;
UMLS CUI : C5555843;
Semantic type(s)
- concept_is_in_subset
- has_target
