Ribocytokine IL-7 BNT152

Preferred Label : Ribocytokine IL-7 BNT152;

NCIt synonyms : Human Interleukin-7 mRNA-encoded BNT152; BNT-152;

NCIt related terms : BNT-152 MRNA;

NCIt definition : A formulation consisting of lipid nanoparticles (LNPs) encapsulating nucleoside-modified messenger RNA (mRNA) encoding the endogenous cytokine interleukin-7 (IL-7), with potential immunostimulating activity. Upon administration, ribocytokine IL-7 BNT152 is taken up by cells and the expressed IL-7 targets and binds to the IL-7 receptor (IL7R). The binding of IL-7 to IL7R activates IL7/IL7R-mediated signaling, which activates B- and T- lymphocytes, may improve immune recovery and activation, and may enhance anti-tumor immune responses.;

UNII : CGW6LTN588;

Molecule name : BNT 152; BNT152;

NCI Metathesaurus CUI : CL1662150;

Details

Origin ID

C179639;

UMLS CUI

C5555834;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Receptor Activation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Lymphocyte Activation Process [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Interleukin-7 Receptor Subunit Alpha [NCIt concept]

Keyword's position in hierarchy(ies) :

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