Preferred Label : Allogeneic Anti-CD7 CAR T Cells;
NCIt synonyms : Donor Anti-CD7 CAR T Cells; Donor-Derived CD7 CAR T Cells;
NCIt definition : A preparation of donor-derived T-lymphocytes that have been genetically engineered
to express a chimeric antigen receptor (CAR) directed against the tumor-associated
antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities.
Upon intravenous administration, the allogeneic anti-CD7 CAR T cells specifically
recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated
tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural
killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic
T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas.;
NCI Metathesaurus CUI : CL1662143;
Origin ID : C179630;
UMLS CUI : C5555826;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
