NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody against C-C-chemokine receptor
7 (CCR7), with potential immunomodulating and antineoplastic activities. Upon administration,
anti-CCR7 monoclonal antibody CAP-100 targets and binds to CCR7 on tumor cells, and
neutralizes ligand-mediated signaling through both ligands CCL19 and CCL21. This prevents
the activity of CCR7 on tumor cells. CAP-100 is expected to prevent the migration
of tumor cells to and their survival in lymphoid niches. In addition, CAP-100 eliminates
CCR7-positive tumor cells via the induction of Fc-mediated antibody-dependent cell-mediated
cytotoxicity (ADCC). CCR7, a G-protein coupled receptor involved in trafficking of
cells to lymph nodes, is normally expressed by subsets of immune cells and overexpressed
in various types of cancer cells, such as in many hematological malignancies. Its
overexpression has been associated with lymph node metastasis and poor survival.;
Semantic type(s)