Anti-TREM2 Monoclonal Antibody PY314

Preferred Label : Anti-TREM2 Monoclonal Antibody PY314;

NCIt definition : A humanized monoclonal antibody targeting triggering receptor expressed on myeloid cells 2 (TREM2; TREM-2), with potential immunomodulating and antineoplastic activities. Upon administration, anti-TREM2 monoclonal antibody PY314 targets and binds to TREM2 located on immunosuppressive tumor-associated myeloid cells within the tumor microenvironment (TME), including tumor associated macrophages (TAMs). This induces antibody dependent cell mediated cytotoxicity (ADCC) and/or antibody dependent cell mediated phagocytosis (ADCP), thereby killing TREM2-positive cells, including TAMs. The depletion of TAMs alters the TME, activates cytotoxic T-lymphocytes (CTLs), natural killer (NK) cells and M1-like macrophages, which stimulate anti-tumor immune responses, and leads to tumor cell destruction. TREM2, an immunoglobulin (Ig) superfamily transmembrane protein, is expressed within the TME and is associated with poorer patient outcomes.;

Molecule name : PY-314; PY 314;

NCI Metathesaurus CUI : CL1662172;

Details

Origin ID

C179597;

UMLS CUI

C5555802;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Triggering Receptor Expressed On Myeloid Cells 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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