Preferred Label : Pan-LOX Inhibitor PXS-5505;
NCIt synonyms : LOX Inhibitor PXS-5505;
NCIt related terms : PXS-5505;
NCIt definition : An orally available, small-molecule, irreversible inhibitor of all lysyl oxidases
(LOX) family members, with potential antifibrotic activity. Upon oral administration,
pan-LOX inhibitor PXS-5505 targets, binds to and inhibits the activity of all enzymes
in the LOX family. This prevents the post-translational oxidative deamination of lysine
residues on target proteins, including collagen and elastin, and reduces the formation
of deaminated lysine (allysine), the formation of inter- and intramolecular cross-linkages
and may prevent remodeling of the extracellular matrix (ECM), thereby reducing fibrotic
tissue formation in certain chronic fibrotic diseases. LOX is often upregulated in
fibrotic tissue and plays a key role in fibrosis.;
UNII : DO94E28WYW;
CAS number : 2409963-83-1;
Molecule name : PXS-5505; PXS 5505;
NCI Metathesaurus CUI : CL1662187;
Origin ID : C179584;
UMLS CUI : C5555791;
Semantic type(s)
- concept_is_in_subset
- has_target
