Preferred Label : Amsulostat;
NCIt synonyms : LOX Inhibitor PXS-5505; Pan-LOX Inhibitor PXS-5505; LOX-IN-3;
NCIt definition : An orally available, small-molecule, irreversible inhibitor of all lysyl oxidases
(LOX) family members, with potential antifibrotic activity. Upon oral administration,
amsulostat targets, binds to and inhibits the activity of all enzymes in the LOX family.
This prevents the post-translational oxidative deamination of lysine residues on target
proteins, including collagen and elastin, and reduces the formation of deaminated
lysine (allysine), the formation of inter- and intramolecular cross-linkages and may
prevent remodeling of the extracellular matrix (ECM), thereby reducing fibrotic tissue
formation in certain chronic fibrotic diseases. LOX is often upregulated in fibrotic
tissue and plays a key role in fibrosis.;
UNII : DO94E28WYW;
CAS number : 2409963-83-1;
Molecule name : PXS-5505; PXS 5505;
NCI Metathesaurus CUI : CL1662187;
Origin ID : C179584;
UMLS CUI : C5555791;
Semantic type(s)
- concept_is_in_subset
- has_target
