Preferred Label : Paclitaxel and Hyaluronic Acid;
NCIt synonyms : P-HA; Paclitaxel/Hyaluronic Acid; Paclitaxel-Hyaluronic Acid;
NCIt definition : A water soluble, muco-adhesive co-formulation composed of the natural taxane paclitaxel
conjugated to the naturally occurring proteoglycan hyaluronic acid, with potential
antineoplastic activity. Upon intravesical administration of paclitaxel and hyaluronic
acid, HA targets and binds to CD44 expressed on cancer cells. In turn, paclitaxel
binds to and stabilizes microtubules, preventing their depolymerization and inhibiting
cellular motility, mitosis, and replication in CD44-expressing tumor cells. CD44,
a transmembrane glycoprotein and HA receptor expressed in healthy tissue, is overexpressed
in a variety of cancer cell types and plays a key role in tumor cell proliferation,
migration and survival.;
Drug name : Oncofid-P-B;
NCI Metathesaurus CUI : CL1662082;
Origin ID : C179565;
UMLS CUI : C5555775;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
