Preferred Label : Allogeneic CD19-CAR CD45RA-negative T-cells;
NCIt synonyms : Allogeneic CD19-CAR(Mem)T-cells; Allogeneic CD45RA-negative T-cells-expressing CD19-specific CAR 41BBz; Allogeneic Anti-CD19-CAR-4-1BBz CD45RA-negative T-cells; Allogeneic CD19-CAR Memory T-cells;
NCIt definition : A preparation of allogeneic T-lymphocytes, depleted of CD45RA-positive cells, that
have been genetically modified to express a chimeric antigen receptor (CAR) targeting
the tumor-associated antigen (TAA) CD19 (cluster of differentiation 19) fused to the
co-stimulatory domain of 4-1BB (CD137) and the CD3-zeta (CD3z) T-cell signaling domain
(4-1BBz), with potential immunostimulating and antineoplastic activities. CD45RA depletion
results in a cellular product that contains a high amount of memory T-cells (Tm).
Upon administration, the allogeneic CD19-CAR CD45RA-negative T-cells specifically
recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic
T-lymphocyte (CTL)-mediated killing of CD19-expressing tumor cells. CD19 antigen is
a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.
CD45RA is expressed on naive T-cells (Tn), whereas Tm cells are CD45RA-negative. The
depletion of the CD45RA-positive cells reduces the risk of graft-versus-host disease
(GvHD) upon infusion. Tn cells have the potential to induce more severe graft-versus-host
disease (GvHD) than Tm cells.;
NCI Metathesaurus CUI : CL1662252;
Origin ID : C179501;
UMLS CUI : C5555728;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
