Preferred Label : Allogeneic Anti-CD19 CAR T-cells PBCAR19B;
NCIt synonyms : Allogeneic Anti-CD19 CAR T Cells PBCAR19B; Allogeneic CD19-targeting CAR-T Cells PBCAR19B; Allogeneic CD19 CAR T-cells PBCAR19B;
NCIt definition : A preparation of allogeneic T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19
(cluster of differentiation 19), a single short hairpin RNA (shRNA) that disrupts
the expression of beta-2 microglobulin (B2M) component of the class 1 major histocompatibility
complex (MHC) molecules, and a HLA-E gene, with potential immunostimulating and antineoplastic
activities. Upon administration, the allogeneic anti-CD19 CAR T-cells PBCAR19B specifically
recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic
T-lymphocyte (CTL)-mediated killing of CD19-expressing tumor cells. The downregulation
of the expression of the class 1 MHC molecule component B2M by shRNA and the HLA-E
gene decrease the number of CAR T-cells that are rejected and killed by natural killer
(NK) and cytotoxic T-cells. CD19 antigen is a B-cell specific cell surface antigen
overexpressed in B-cell lineage malignancies.;
Molecule name : PBCAR19B;
NCI Metathesaurus CUI : CL1661874;
Origin ID : C179301;
UMLS CUI : C5555595;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
