Preferred Label : Lutetium Lu-177 PNT2002;
NCIt synonyms : Lutetium Lu-177-PNT2002; Lu177-PNT2002; [Lu-177]-PSMA-I and T; 177Lu-labeled PNT2002; [Lu-177]-PNT2002; 177Lu-PNT2002;
NCIt definition : A radioconjugate composed of PNT2002, a human prostate-specific membrane antigen (PSMA)-targeting
ligand, conjugated to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with
potential antineoplastic activity. Upon administration of lutetium Lu-177 PNT2002,
the PNT2002 moiety targets and binds to PSMA-expressing tumor cells. Upon binding,
PSMA-expressing tumor cells are destroyed by 177Lu through the specific delivery of
beta particle radiation. PSMA, a tumor-associated antigen (TAA) and type II transmembrane
protein, is expressed on the membrane of prostatic epithelial cells and overexpressed
on the majority of prostate tumor cells.;
NCI Metathesaurus CUI : CL1661875;
Origin ID : C179300;
UMLS CUI : C5555594;
Semantic type(s)
- concept_is_in_subset
- has_target
