Preferred Label : ATR Inhibitor ART0380;
NCIt definition : An orally bioavailable inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase,
with potential antineoplastic activity. Upon oral administration, ATR inhibitor ART0380
selectively targets and inhibits ATR activity and blocks the downstream phosphorylation
of the serine/threonine protein kinase checkpoint kinase 1 (CHK1). This prevents ATR-mediated
signaling, which results in the inhibition of DNA damage checkpoint activation, the
disruption of DNA damage repair, and the induction of tumor cell apoptosis. ATR, a
serine/threonine protein kinase upregulated in a variety of cancer cell types, plays
a key role in DNA repair, cell cycle progression and survival. It is activated by
DNA damage caused during DNA replication-associated stress.;
Molecule name : ART-0380; ART 0380;
NCI Metathesaurus CUI : CL1661895;
Origin ID : C179292;
UMLS CUI : C5555590;
Semantic type(s)
- concept_is_in_subset
- has_target
