NCIt definition : An orally bioavailable and irreversible covalent inhibitor of Bruton's tyrosine kinase
(BTK), with potential antineoplastic activity. Upon administration, BTK inhibitor
JNJ-64264681 targets, binds to and inhibits the activity of BTK and prevents the activation
of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell
activation and BTK-mediated activation of downstream survival pathways. This leads
to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member
of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed
in B-cell malignancies; it plays an important role in B lymphocyte development, activation,
signaling, proliferation and survival.;
Semantic type(s)