NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody against the pro-inflammatory
cytokine interleukin-18 (IL-18), with potential anti-inflammatory and antineoplastic
activities. Upon administration, camoteskimab selectively targets and binds to IL-18,
thereby inhibiting IL-18-mediated signaling and inflammation mediated by this pathway.
In addition, this may inhibit IL-18-mediated immunosuppression in the multiple myeloma
microenvironment. IL-18 is a member of the interleukin-1 (IL-1) cytokine superfamily.
Elevated IL-18 level is associated with disease progression and poor prognosis in
multiple myeloma.;
UNII : ONX021SC9O;
CAS number : 2492472-82-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2492472-82-7
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G-SRS /a ;
Molecule name : CERC 007; MEDI2338; AEVI-007; CERC-007;
Semantic type(s)