NCIt definition : A bispecific antibody and a T-cell engager targeting both the tumor-associated antigen
(TAA) CD19, and the T-cell surface antigen CD3, with potential immunostimulating and
antineoplastic activities. Upon administration, anti-CD19/CD3 bispecific antibody
GNR-084 binds to both the CD3 antigen on T-cells and the CD19 antigen expressed on
tumor cells. This results in the cross-linking of T-cells and tumor cells, and induces
a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells. CD19
antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage
malignancies.;
Semantic type(s)