Preferred Label : SHP2 Inhibitor PF-07284892;
NCIt related terms : PF-07284892;
NCIt definition : A small molecule inhibitor of protein tyrosine phosphatase (PTP) non-receptor type
11 (SHP2; Src homology region 2 domain phosphatase; PTPN11), with potential antineoplastic
activity. Upon administration, SHP2 inhibitor PF-07284892 targets, binds to and inhibits
the activity of SHP2. This prevents SHP2-mediated signaling, inhibits MAPK signaling
and prevents growth of SHP2-expressing tumor cells. SHP2, an oncoprotein overexpressed
in a variety of cancer cell types, regulates cell survival, differentiation and proliferation
through activation of the Ras-Raf-MEK-ERK signaling pathway. The Ras-MAPK pathway
is often hyperactivated in cancer cells due to specific mutations and rearrangements,
and are dependent on SHP2 for their oncogenic signaling. SHP2 also regulates programmed
cell death 1 (PD-1)-mediated signal transduction and is involved in immune checkpoint
modulation.;
UNII : K3M925R42M;
CAS number : 2498597-94-5;
Molecule name : ARRY 558; ARRY-558; PF 07284892; PF-07284892;
NCI Metathesaurus CUI : CL1648109;
Origin ID : C178469;
UMLS CUI : C5555061;
Semantic type(s)
- concept_is_in_subset
- has_target
