Preferred Label : DHODH Inhibitor JNJ-74856665;
NCIt synonyms : Dihydroorotate Dehydrogenase Inhibitor JNJ-74856665;
NCIt definition : An orally available inhibitor of dihydroorotate dehydrogenase (DHODH), with potential
antineoplastic activity. Upon oral administration, DHODH inhibitor JNJ-74856665 specifically
targets and binds to DHODH's ubiquinone binding site, thereby preventing the activation
of DHODH. This prevents the fourth enzymatic step in de novo pyrimidine synthesis.
This prevents uridine monophosphate (UMP) formation, DNA synthesis, cell division
and cellular proliferation, causes reactive oxygen species (ROS) formation, enables
differentiation, causes cell cycle arrest and induces apoptosis in susceptible tumor
cells. DHODH, a mitochondrial enzyme, catalyzes the conversion of dihydroorotate (DHO)
to orotate in the endogenous synthesis of UMP.;
Molecule name : JNJ-74856665; JNJ 74856665;
NCI Metathesaurus CUI : CL1648125;
Origin ID : C178454;
UMLS CUI : C5555047;
Semantic type(s)
- concept_is_in_subset
- has_target
