Preferred Label : Allogeneic CD19CAR-CD28-CD3-zeta-expressing T-lymphocytes;
NCIt synonyms : Allogeneic CD19-28z CAR T Cells; Allogeneic 19-28z CAR-T Cells; Allogeneic 19-28z CAR T-cells;
NCIt definition : A preparation of allogeneic, donor-derived T-lymphocytes that have been genetically
modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv
(single chain variable fragment), fused to the extracellular, transmembrane and intracellular
signaling domains of the T-cell co-stimulatory receptor CD28 and the cytoplasmic signaling
domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (19-28z), with potential
immunostimulating and antineoplastic activities. Upon administration, allogeneic CD19CAR-CD28-CD3-zeta-expressing
T-lymphocytes are directed to CD19-expressing tumor cells, which induces selective
toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface
antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule
signaling domain enhances activation and signaling after recognition of CD19. The
inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor
activity compared to the inclusion of the CD3-zeta chain alone.;
NCI Metathesaurus CUI : CL1648135;
Origin ID : C178433;
UMLS CUI : C5555028;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
