Preferred Label : Universal Anti-CD7 CAR T Cells RD13-01;
NCIt synonyms : Universal CAR-T Cells Targeting CD7;
NCIt definition : A preparation of universal T-lymphocytes that have been genetically engineered to
express a chimeric antigen receptor (CAR) directed against the tumor-associated antigen
(TAA) CD7, with potential immunostimulating and antineoplastic activities. Upon administration,
universal anti-CD7 CAR T cells RD13-01 specifically recognize and bind to CD7-expressing
tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane
glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors.
It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and
in a subset of peripheral T-cell lymphomas.;
Molecule name : RD13 01; RD13-01;
NCI Metathesaurus CUI : CL1647841;
Origin ID : C178419;
UMLS CUI : C5555020;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
