Preferred Label : Anti-mucin-1/PE Immunoconjugate BM7PE;
NCIt synonyms : Immunotoxin BM7PE; Anti-MUC1/PE BM7PE;
NCIt definition : An immunoconjugate containing BM7, a murine monoclonal antibody directed against the
human tumor-associated antigen (TAA) mucin-1 (MUC1; MUC-1) covalently linked to the
bacterial toxin Pseudomonas exotoxin A (PE), with potential antitumor activity. Upon
administration of BM7PE, the antibody moiety targets and binds to MUC1. In turn, the
PE moiety inhibits protein synthesis via modifying translation elongation factor 2
(EF-2), thereby causing apoptosis and inhibiting tumor cell growth and proliferation
in MUC1-overexressing cancer cells. MUC1, a type I transmembrane protein, is overexpressed
in a variety of tumor types. It plays an important role in cancer progression and
metastasis.;
Molecule name : BM7 PE; BM7-PE;
NCI Metathesaurus CUI : CL1647862;
Origin ID : C178406;
UMLS CUI : C5555013;
Semantic type(s)
- concept_is_in_subset
- has_target
