" /> Izalontamab - CISMeF





Preferred Label : Izalontamab;

NCIt synonyms : EGFR/HER3 Bispecific Antibody SI-B001; HER3 x EGFR SI-B001; Anti-EGFR/anti-HER3 Bi-specific Monoclonal Antibody SI-B001; Anti-EGFR/HER3 Bispecific Antibody SI-B001;

NCIt definition : An immunoglobulin G (IgG) bispecific antibody targeting both the epidermal growth factor receptor (EGFR; HER1; ErbB1) and the epidermal growth factor receptor 3 (HER3; ErbB3), with potential antineoplastic activity. Upon administration, izalontamab simultaneously targets and binds to EGFR and HER3 expressed on cancer cells, thereby preventing receptor phosphorylation. This prevents the activation of both EGFR- and HER3-mediated signaling pathways and results in the inhibition of tumor cell proliferation. EGFR and HER3, both upregulated and/or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation.;

UNII : S8YH2C9NLA;

CAS number : 2559704-24-2;

Molecule name : SI-B001; SI B001;

NCI Metathesaurus CUI : CL1647846;

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10/05/2025


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