Preferred Label : CBP/p300 Bromodomain Inhibitor FT-7051;
NCIt synonyms : p300/CBP Bromodomain Inhibitor FT-7051;
NCIt definition : An orally bioavailable inhibitor of the bromodomain of the histone acetyltransferase
(HAT) paralogs, CREB binding protein (CBP) and p300 (E1A-associated protein p300;
p300 HAT), with potential antineoplastic activity. Upon oral administration, CBP/p300
bromodomain inhibitor FT-7051 targets and binds to the bromodomain of CBP and p300.
This disrupts the acetylation of histones and other proteins and prevents the co-activation
of the androgen receptor (AR) including AR-v7. This may inhibit tumor cell proliferation
in AR-positive tumor cells. The HAT paralogs CBP and p300 are key transcriptional
co-activators that are essential for a multitude of cellular processes and are implicated
in the progression and therapeutic resistance of certain cancers.;
Molecule name : FT-7051; FT 7051;
NCI Metathesaurus CUI : CL1647801;
Origin ID : C178370;
UMLS CUI : C5554986;
Semantic type(s)
- concept_is_in_subset
- has_target
