Preferred Label : Anti-GITR AgonisticMonoclonal Antibody REGN6569;
NCIt definition : An agonistic monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor
receptor (GITR; tumor necrosis factor superfamily member 18; TNFRSF18; CD357), with
potential immune checkpoint modulating and antineoplastic activities. Upon administration,
anti-GITR agonistic monoclonal antibody REGN6569 targets, binds to and activates GITR,
which is expressed on the cell surface of multiple types of T-lymphocytes and other
immune cells. This induces both the activation and proliferation of tumor antigen-specific
T-effector cells (Teffs), and suppresses the function of activated T-regulatory cells
(Tregs), which may promote the elimination of tumor cells. GITR, a member of the TNF
receptor superfamily and T-cell receptor co-stimulator, is expressed on the surface
of multiple immune cell types, including Tregs, Teffs, B-cells, and natural killer
(NK) cells. Inappropriately activated Tregs suppress both Teffs and T-cell receptor
(TCR) signaling.;
Molecule name : REGN-6569; REGN 6569;
NCI Metathesaurus CUI : CL1647837;
Origin ID : C178331;
UMLS CUI : C5554956;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
