Hsp90 Inhibitor NVP-BEP800

Preferred Label : Hsp90 Inhibitor NVP-BEP800;

NCIt synonyms : Heat Shock Protein 90 Inhibitor NVP-BEP800;

NCIt related terms : 2-AMINO-4-(2,4-DICHLORO-5-(2-(1-PYRROLIDINYL)ETHOXY)PHENYL)-N-ETHYLTHIENO(2,3-D)PYRIMIDINE-6-CARBOXAMIDE;

NCIt definition : An orally bioavailable inhibitor of heat shock protein 90 (Hsp90), with potential antineoplastic activity. Upon oral administration, Hsp90 inhibitor NVP-BEP800 specifically binds to the NH(2)-terminal ATP-binding pocket of Hsp90 and specifically blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival, including ErbB2, B-Raf(V600E), Raf-1, and Akt. This prevents oncogenic pathway signaling mediated by these proteins and leads to the inhibition of tumor cell proliferation. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins.;

UNII : GWB3R6VBE7;

CAS number : 847559-80-2;

Molecule name : NVP-BEP800; NVP BEP800; VER-82576;

NCI Metathesaurus CUI : CL1647936;

Details

Origin ID

C178311;

UMLS CUI

C2931963;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NVP-BEP800 [MeSH Supplementary Concept]
- NVP-BEP800 [MeSH concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Heat Shock Protein 90 [NCIt concept]

Keyword's position in hierarchy(ies) :

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