Preferred Label : Anti-FOXP3 Antisense Oligonucleotide AZD8701;
NCIt synonyms : FOXP3-targeting Antisense Oligonucleotide AZD8701; Anti-FOXP3 ASO AZD8701;
NCIt definition : An antisense oligonucleotide (ASO) targeting the Forkhead Box P3 (FOXP3) mRNA, with
potential immunomodulating and antineoplastic activities. Upon administration, anti-FOXP3
ASO AZD8701 blocks the translation of the FOXP3 protein. Reduction of FOXP3 levels
may lessen the immunosuppressive functions of regulatory T-cells (Tregs). This may
lead to an enhanced immune response and antitumor activity. FOXP3, a transcription
factor, plays an important role in the functioning of immunosuppressive Tregs. Tregs
are overexpressed in various cancers and are associated with poor response to immune
checkpoint inhibitors and poor survival.;
Molecule name : ION 736; AZD 8701; IONIS-AZ7-2.5Rx; ION-736; AZD-8701;
NCI Metathesaurus CUI : CL1647931;
Origin ID : C178282;
UMLS CUI : C5554917;
Semantic type(s)
- concept_is_in_subset
- has_target
