Preferred Label : Polzastobart;
NCIt synonyms : Anti-ILT4 Monoclonal Antibody JTX-8064; Anti-LILRB2 Monoclonal Antibody JTX-8064;
NCIt definition : A humanized monoclonal antibody directed against the inhibitory immune checkpoint
receptor leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2; immunoglobulin-like
transcript 4; ILT4; lymphocyte immunoglobulin-like receptor 2; LIR2; monocyte/macrophage
immunoglobulin-like receptor 10; MIR-10; CD85d), with potential immunomodulating and
antineoplastic activities. Upon administration, polzastobart targets and binds to
LILRB2. This prevents the binding of LILRB2 ligands, including endogenous major histocompatibility
complex class I (MHC I) molecules, to their receptor and prevents LILRB2-mediated
signaling. This may abrogate the immunosuppressive activities of LILRB2 in the tumor
microenvironment (TME), activate the expression of pro-inflammatory cytokines, including
GM-CSF and tumor necrosis factor alpha (TNFalpha), and enhance a cytotoxic T-lymphocyte
(CTL)-mediated anti-tumor immune response. LILRB2, expressed primarily by myeloid
cells, including monocytes, macrophages, dendritic cells (DCs) and granulocytes, and
certain tumor cells, plays a key role in tumor immune evasion.;
UNII : 0ENU8YY1SS;
CAS number : 2640981-19-5;
Molecule name : JTX-8064; JTX 8064;
NCI Metathesaurus CUI : CL1647934;
Origin ID : C178281;
UMLS CUI : C5706698;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
