Preferred Label : Ras Inhibitor RSC-1255;
NCIt definition : An orally bioavailable pan-mutant and wild-type Ras inhibitor, with potential antineoplastic
activity. Upon oral administration, Ras inhibitor RSC-1255 selectively targets, binds
to and inhibits both wild-type and mutated forms of Ras, thereby inhibiting Ras-dependent
signaling and inhibits proliferation of tumor cells in which Ras is overexpressed
and/or mutated. Ras serves an important role in cell signaling, division and differentiation.
Mutations of Ras may induce constitutive signal transduction leading to tumor cell
growth, proliferation, invasion, and metastasis.;
Molecule name : RSC-1255; RSC 1255;
NCI Metathesaurus CUI : CL1647976;
Origin ID : C178264;
UMLS CUI : C5554908;
Semantic type(s)
- concept_is_in_subset
- has_target
