NCIt definition : A peptide-drug conjugate composed of the second-generation taxane docetaxel and the
sortilin (SORT1)-targeting peptide zendusortide (TH19P01), with potential antineoplastic
activity. Upon administration of sudocetaxel zendusortide, the zendusortide moiety
targets and binds to SORT1 expressed on tumor cells. Upon internalization, docetaxel
binds to and stabilizes the beta-tubulin subunit, thereby inhibiting microtubule disassembly
which results in cell-cycle arrest at the G2/M phase and cell death. SORT1 is overexpressed
in a variety of cancers and plays an important role in protein internalization, sorting
and trafficking.;
Semantic type(s)