Preferred Label : Allogeneic Anti-CD70-CAR T-cells ALLO-316;
NCIt synonyms : Anti-CD70 AlloCAR T-cells ALLO-316; Allogeneic TALEN-edited Anti-CD70-CAR T-cells ALLO-316; AlloCAR T (TM) ALLO-316;
NCIt definition : An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes obtained from
healthy donors that are engineered to express a chimeric antigen receptor (CAR) specific
for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70)
and gene-edited with transcription activator-like effector nuclease (TALEN) to inactivate
the endogenous T-cell receptor alpha constant (TRAC) and CD52 loci, with potential
immunostimulating and antineoplastic activities. Upon introduction into the patient,
the allogeneic anti-CD70-CAR T-cells ALLO-316 recognize and bind to CD70-expressing
tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing
of CD70-positive tumor cells. CD70, a type II transmembrane glycoprotein and member
of the tumor necrosis factor (TNF) family, is found on the surfaces of various types
of cancer cells. Deletion of the CD52 gene makes the modified donor T-cells resistant
to anti-CD52 monoclonal antibodies, which can be used during lymphodepletion. The
deletion of the TRAC gene abrogates the potential induction of graft-versus-host disease
(GvHD) by the donor T-cells.;
Molecule name : ALLO-316; ALLO 316;
NCI Metathesaurus CUI : CL1647712;
Origin ID : C177917;
UMLS CUI : C5554748;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
