Preferred Label : Anti-CD70 Monoclonal Antibody SEA-CD70;
NCIt synonyms : Anti-CD70 Fully Human Monoclonal Antibody MDX-1411; Sugar-engineered Antibody CD70;
NCIt definition : A humanized, nonfucosylated monoclonal antibody directed against the human CD70 antigen,
with potential immunomodulatory and antineoplastic activities. Upon administration,
anti-CD70 monoclonal antibody sugar-engineered antibody (SEA)-CD70 selectivity targets
and binds to the extracellular domain of CD70, which blocks CD70-mediated signaling.
This may inhibit cellular proliferation and survival of CD70-expressing tumor cells,
and may modulate the immune system to inhibit inflammatory signals and increase antigen-specific
T-cell responses in the tumor microenvironment (TME). In addition, SEA-CD70 induces
antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis
(ADCP), and complement-dependent cytotoxicity (CDC) against CD70-expressing tumor
cells. CD70, a member of the tumor necrosis factor (TNF) family, is aberrantly expressed
on malignant myeloid blasts while absent from healthy hematopoietic progenitor cells.;
Molecule name : SEA-CD70; SEA CD70;
NCI Metathesaurus CUI : CL1647511;
Origin ID : C177902;
UMLS CUI : C5554734;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
