" /> Anti-DLL3/CD3 Bispecific Antibody BI 764532 - CISMeF





Preferred Label : Anti-DLL3/CD3 Bispecific Antibody BI 764532;

NCIt synonyms : DLL3/CD3 Bispecific Antibody BI 764532; T-cell Engager BI 764532;

NCIt definition : A bispecific T-cell engager antibody directed against both the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-DLL3/CD3 bispecific antibody BI 764532 binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.;

Molecule name : BI-764532; BI 764532;

NCI Metathesaurus CUI : CL1647547;

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Keyword's position in hierarchy(ies) : arborescence

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12/05/2024


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