NCIt synonyms : DLL3/CD3 Bispecific Antibody BI 764532; T-cell Engager BI 764532; Anti-DLL3/CD3 Bispecific Antibody BI 764532;
NCIt definition : A bispecific T-cell engager antibody directed against both the tumor-associated antigen
(TAA) delta-like protein 3 (DLL3) and the CD3 antigen found on T-lymphocytes, with
potential immunostimulating and antineoplastic activities. Upon administration, obrixtamig
binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen
on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing
tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor
cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell
types. It plays a key role in embryonic development and in tumor initiation and proliferation.;
Semantic type(s)