Preferred Label : Oncogene ERB B;
NCIt synonyms : Avian Erythroblastosis Virus Oncogene B; Oncogene, EGFR; ERB-B; Erythroblast Transforming Gene B; Oncogene ERB-B;
NCIt definition : ERBB DNA sequences are related to certain avian erythroblastosis virus sequences.
The cellular genes encode members of the epidermal growth factor receptor (EGFR) family
(ERBB1, 2, 3, and 4). The 110-kb EGFR gene locus encodes the EGF receptor, a cell
surface transmembrane protein tyrosine kinase involved in regulation of cell growth
and differentiation. ERBB2, ERBB3, and ERBB4 genes encode heregulin/neuregulin receptor
tyrosine kinase homo- and heterodimers important in the control of cell proliferation
and in the pathogenesis of human cancers. ERBB proteins are over expressed in a significant
portion of adenocarcinomas at various sites, especially in the breast; gene amplification
appears to be the predominant cause of over expression. Oncogene ERBB2 encodes tumor
antigen p185. The human ERBB1 gene is located at 7p12.3-p12.1, ERBB2 is located at
17p12-21, ERBB3 is located at 12q13, ERBB4 is located at 2q33.3-q34.;
GenBank Accession Number : X00588;
Origin ID : C17763;
UMLS CUI : C0243036;
Automatic exact mappings (from CISMeF team)
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_associated_with_disease
- gene_found_in_organism
- gene_in_chromosomal_location
- gene_plays_role_in_process
