Preferred Label : Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing Natural Killer T-cells;
NCIt synonyms : Allogeneic Anti-CD19-CAR-IL-15-expressing Natural Killer T-cells; CD19.CAR Allogeneic NKT Cells; Allogeneic Anti-CD19-CAR-CD28-IL-15-expressing NKTs; Allogeneic Anti-CD19 CAR/IL-15-expressing Natural Killer T-cells; CD19.CAR-aNKTs; CD19.CAR-aNKT Cells;
NCIt definition : A preparation of allogeneic natural killer T-lymphocytes (NKTs) that have been engineered
to express a chimeric antigen receptor (CAR) specific for the human tumor associated
antigen (TAA) CD19, interleukin 15 (IL-15) and the costimulatory T-cell-specific surface
glycoprotein CD28, with potential immunostimulating and antineoplastic activities.
Upon administration, allogeneic anti-CD19-CAR-CD28-IL-15-expressing NKTs target, bind
to, and induce selective toxicity in CD19-expressing tumor cells. IL-15 is a pro-survival
cytokine that promotes T-cell persistence and potentiates the immune response against
tumor cells. CD28 costimulatory molecule enhances activation and signaling after recognition
of CD19, and may increase proliferation of T-cells and antitumor activity. CD19 antigen
is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.;
NCI Metathesaurus CUI : CL1643232;
Origin ID : C177533;
UMLS CUI : C5447838;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
