Preferred Label : Anti-TYRP1/CD3 T-cell Engager RO7293583;
NCIt synonyms : Anti-gp75/CD3 T-cell Engager RO7293583; Anti-TRP1/CD3 T-cell Engager RO7293583; TYRP1-targeting CD3 T-cell Engager RO7293583;
NCIt definition : A bispecific T-cell engager directed against the tumor-associated antigen (TAA) tyrosinase-related
protein 1 (TYRP1; TRP1; glycoprotein 75; gp75) and the CD3 antigen found on T-lymphocytes,
with potential immunostimulating and antineoplastic activities. Upon administration,
anti-TYRP1/CD3 T-cell engager RO7293583 binds to both CD3 on cytotoxic T-lymphocytes
(CTLs) and TYRP1 found on TYRP1-expressing tumor cells. This activates and redirects
CTLs to TYRP1-expressing tumor cells, which results in the CTL-mediated death of TYRP1-expressing
tumor cells. TYRP1, a transmembrane glycoprotein, is involved in melanin biosynthesis
and is expressed in melanosomes of human melanocytes and melanomas.;
Molecule name : RO 7293583; RO-7293583;
NCI Metathesaurus CUI : CL1643311;
Origin ID : C177437;
UMLS CUI : C5447766;
Semantic type(s)
- concept_is_in_subset
- has_target
