Preferred Label : Anti-MUC1/EGFR Bispecific Antibody Drug Conjugate M1231;
NCIt synonyms : ADC M1231; Anti-MUC1/EGFR ADC M1231; Anti-MUC1/EGFR Bispecific ADC M1231;
NCIt definition : An antibody drug conjugate (ADC) composed of a bispecific antibody directed against
the tumor associated antigens (TAAs) mucin-1 (MUC1) and human epidermal growth factor
receptor (EGFR), conjugated, via a cleavable valine-citruline-based linker, to the
hemiasterlin-related toxic warhead, with potential antineoplastic activity. Upon intravenous
administration, the antibody moiety of anti-MUC1/EGFR bispecific ADC M1231 targets
and binds to MUC1 and EGFR expressed on certain tumor cells. Upon binding, internalization,
and enzymatic cleavage, the cytotoxic hemiasterlin moiety of M1231 binds to the vinca
domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule
assembly, depolymerization of existing microtubules, inhibition of mitosis, and inhibition
of cellular proliferation. MUC1 and EGFR, overexpressed on the surface of a variety
of cancer cells, play key roles in tumor cell survival and proliferation. MUC1 and
EGFR are often co-localized due to loss of membrane polarization on tumor cells while
co-expression in normal cells is limited.;
Molecule name : M 12231; M-1231;
NCI Metathesaurus CUI : CL1642945;
Origin ID : C177111;
UMLS CUI : C5447588;
Semantic type(s)
- concept_is_in_subset
- has_target
