Preferred Label : Anti-CD73 Monoclonal Antibody Sym024;
NCIt definition : A monoclonal antibody targeting the ectoenzyme 5'-ecto-nucleotidase (cluster of differentiation
73; CD73; 5'-NT; ecto-5'-nucleotidase; NT5E), with potential immunomodulating and
antineoplastic activities. Upon administration, anti-CD73 monoclonal antibody Sym024
targets and binds to CD73 on tumor cells, thereby inhibiting CD73 activity. This prevents
CD73-mediated conversion of extracellular adenosine monophosphate (AMP) to adenosine,
preventing adenosine-mediated suppression of lymphocyte activity and increasing the
activity of cytotoxic T-lymphocytes (CTLs). This also activates macrophages and reduces
the activity of both myeloid-derived suppressor cells (MDSCs) and regulatory T-lymphocytes
(Tregs). By abrogating the inhibitory effect on the immune system and enhancing the
CTL-mediated immune response against cancer cells, tumor cell growth is decreased.
CD73, a plasma membrane protein belonging to the 5'-nucleotidase (NTase) family, is
upregulated on a number of cancer cell types and catalyzes the conversion of extracellular
nucleotides, such as AMP, to membrane-permeable nucleosides, such as adenosine; it
plays a key role in adenosine-mediated immunosuppression within the tumor microenvironment
(TME).;
Molecule name : Sym 024; Sym-024;
NCI Metathesaurus CUI : CL1642786;
Origin ID : C176987;
UMLS CUI : C5447538;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
