Superficial Atypical Lipomatous Tumor

Preferred Label : Superficial Atypical Lipomatous Tumor;

NCIt synonyms : Superficial Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma; Superficial Atypical Lipomatous Tumor/Well Differentiated Liposarcoma; Superficial Well-Differentiated Liposarcoma; Superficial ALT/WDLPS; Superficial ALT;

NCIt related terms : Well differentiated liposarcoma of superficial soft tissue; Superficial well differentiated liposarcoma;

NCIt definition : A locally aggressive mesenchymal neoplasm of a superficial body structure that is characterized by the presence of an adipocytic proliferation exhibiting at least focal nuclear atypia in both adipocytes and stromal cells. Amplification of MDM2 and/or CDK4 is almost always present.;

Neoplastic status : Undetermined;

NCI Metathesaurus CUI : CL1642763;

Details

Origin ID

C176980;

UMLS CUI

C5444610;

Disease excludes normal cell origin
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
Disease may have findings
- Well-Circumscribed Lesion [NCIt concept]
Excludes anatomical site(s)
- Bone [NCIt concept]
Has associated anatomic sites
- Connective and Soft Tissue [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
disease_has_abnormal_cell
- Atypical Adipocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Connective and Soft Tissue Cell [NCIt concept]
- Neoplastic Lipocyte [NCIt concept]
- Neoplastic Mature Adipocyte [NCIt concept]
disease_has_finding
- Locally Aggressive Lesion [NCIt concept]
- Superficial Lesion [NCIt concept]
disease_has_normal_cell_origin
- Adipocyte [NCIt concept]
- Connective and Soft Tissue Cell [NCIt concept]
disease_has_normal_tissue_origin
- Adipose Tissue [NCIt concept]
- Connective and Soft Tissue [NCIt concept]
- Soft Tissue [NCIt concept]
disease_mapped_to_chromosome
- Human Chromosome 1 [NCIt concept]
- Human Chromosome 12 [NCIt concept]
disease_mapped_to_gene
- MDM2 Gene [NCIt concept]
disease_may_have_abnormal_cell
- Monovacuolated Lipoblast [NCIt concept]
- Multivacuolated Lipoblast [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 12q [NCIt concept]
- Gain of Chromosome 1q [NCIt concept]
- Giant Rod Chromosome [NCIt concept]
- Supernumerary Circular Chromosome [NCIt concept]
disease_may_have_molecular_abnormality
- CDK4 Gene Amplification [NCIt concept]
- MDM2 Gene Amplification [NCIt concept]

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