Preferred Label : PI3Kdelta/gamma Inhibitor ZX-101A;
NCIt synonyms : PI3K-delta/gamma Inhibitor ZX-101A; PI3K-d/g Inhibitor ZX-101A;
NCIt definition : An orally bioavailable inhibitor of the delta and gamma isoforms of phosphoinositide-3
kinase (PI3K), with potential antineoplastic activity. Upon administration of PI3Kdelta/gamma
inhibitor ZX-101A, this agent targets and inhibits the PI3K delta and gamma isoforms
and prevents the activation of the PI3K/AKT-mediated signaling pathway. This may lead
to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells.
ZX-101A may also promote anti-tumor immunity. Unlike other isoforms of PI3K, the delta
and gamma isoforms are overexpressed primarily in hematologic malignancies. By selectively
targeting these isoforms, PI3K signaling in normal, non-neoplastic cells is minimally
impacted or not affected at all, which minimizes the side effect profile for this
agent.;
Molecule name : ZX 101A; ZX-101A;
NCI Metathesaurus CUI : CL1642921;
Origin ID : C176879;
UMLS CUI : C5447493;
Semantic type(s)
- concept_is_in_subset
- has_target
