NCIt definition : A recombinant human monoclonal antibody targeting the co-inhibitory molecule and immune
checkpoint inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor
tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with potential immune checkpoint
inhibitory activity. Upon administration, tamgiblimab targets and binds to TIGIT expressed
on various immune cells, particularly on tumor-infiltrating lymphocytes (TILs), thereby
preventing the interaction of TIGIT with its ligands CD112 (nectin-2; poliovirus receptor
related-2; PRR2; PVRL2) and CD155 (poliovirus receptor; PVR; nectin-like protein 5;
NECL-5). This enhances the interaction of CD112 and CD155 with the costimulatory receptor
CD226 (DNAX Accessory molecule-1; DNAM-1), which is expressed on immune cells, such
as natural killer (NK) cells and CD8 T-cells. This leads to CD226 dimerization and
CD226-mediated signaling and activates the immune system to exert a T-cell-mediated
immune response against cancer cells. TIGIT, a member of the Ig super family (IgSF)
and an immune inhibitory receptor, plays a key role in the suppression of T-cell proliferation
and activation; it is involved in tumor cell immune evasion, and the inhibition of
antiviral immune responses.;
Semantic type(s)