Preferred Label : Lutetium Lu 177-DOTA-ABM-5G;
NCIt synonyms : [177Lu]-DOTA-ABM-5G;
NCIt definition : A radioconjugate composed of 5G, an integrin alphaVbeta6 (aVb6)-targeting peptide,
conjugated, via the bifunctional, macrocyclic chelating agent 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic
acid (DOTA) to the beta-emitting radioisotope lutetium Lu 177, and an albumin-binding
moiety (ABM), with potential antineoplastic activity. Upon administration of lutetium
Lu 177-DOTA-ABM-5G, the 5G moiety selectively targets and binds to integrin aVb6-expressing
tumor cells. Upon binding, aVb6-expressing tumor cells are destroyed by 177Lu through
the specific delivery of beta particle radiation. This agent also binds to serum albumin
with its albumin-binding moiety, which increases the agent's half-life and decreases
its rate of clearance. Integrin aVb6, a cell adhesion and signaling receptor, is upregulated
in certain cancer cell types and has been associated with increased proliferation,
migration and invasion of tumor cells.;
NCI Metathesaurus CUI : CL1642732;
Origin ID : C176853;
UMLS CUI : C5447473;
Semantic type(s)
- concept_is_in_subset
- has_target
