Preferred Label : Gallium Ga 68-DOTA-5G;
NCIt synonyms : [68Ga]-DOTA-5G;
NCIt definition : A radioconjugate composed of 5G, an integrin alphaVbeta6 (aVb6)-targeting peptide,
conjugated, via the bifunctional, macrocyclic chelating agent 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic
acid (DOTA) to the radioisotope gallium Ga 68, with potential use as a tracer for
integrin aVb6-expressing tumor cells during positron emission tomography (PET). Upon
administration of gallium Ga 68-DOTA-5G, the 5G moiety targets and binds to integrin
aVb6 expressed on tumor cells. Upon binding, integrin aVb6-expressing tumor cells
can be detected during PET imaging. Integrin aVb6, a cell adhesion and signaling receptor,
is upregulated in certain cancer cell types and has been associated with increased
proliferation, migration and invasion of tumor cells.;
NCI Metathesaurus CUI : CL1642608;
Origin ID : C176852;
UMLS CUI : C5447472;
Semantic type(s)
- concept_is_in_subset
- has_target
