Preferred Label : Fluorine F 18 DPA-714;
NCIt synonyms : [18F]-DPA-714; [18F]DPA-714;
NCIt definition : A radioconjugate composed of DPA-714, a ligand for the 18 kDa translocator protein
(TSPO), and labeled with the positron-emitting isotope fluorine F 18, that can be
used as a diagnostic imaging agent to detect TSPO-expressing cells using positron
emission tomography (PET). Upon administration of fluorine F 18 DPA-714, the DPA-714
moiety targets and binds to TSPO-expressing cells. Upon PET, fluorine F 18 can be
detected and TSPO-expressing cells can be visualized. This can facilitate detection
of inflammatory sites and cancer cells. TSPO, also called the peripheral benzodiazepine
receptor (PBR), is found on the outer mitochondrial membrane and is overexpressed
on a variety of cancer cells, tumor-infiltrating macrophages, and during inflammation.;
NCI Metathesaurus CUI : CL1642563;
Origin ID : C176774;
UMLS CUI : C5447430;
Semantic type(s)
- concept_is_in_subset
- has_target
