Preferred Label : JAK2 Inhibitor TQ05105;
NCIt definition : An orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2), with potential
antineoplastic activity. Upon oral administration, JAK2 inhibitor TQ05105 inhibits
JAK2 activity, thereby preventing the activation of the JAK/STAT (signal transducer
and activator of transcription) signaling pathway and the activation of STAT3. This
may lead to an induction of tumor cell apoptosis and a decrease in tumor cell proliferation.
JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation
and plays a key role in tumor cell proliferation and survival.;
Molecule name : TQ 05105; TQ-05105;
NCI Metathesaurus CUI : CL1642587;
Origin ID : C176751;
UMLS CUI : C5447414;
Semantic type(s)
- concept_is_in_subset
- has_target
