Preferred Label : Actinium Ac 225-DOTA-h11B6 JNJ-69086420;
NCIt synonyms : [225Ac]-DOTA-h11B6; Actinium-225-labeled h11B6 JNJ-69086420; Actinium-225-labeled Anti-kallikrein-2 h11B6 JNJ-69086420; Actinium Ac 225 Lintuzumab; 225Ac-h11B6 JNJ-69086420;
NCIt definition : A radioimmunoconjugate containing h11B6, a humanized immunoglobulin G1 (IgG1) monoclonal
antibody that targets human kallikrein-2 (hK2), conjugated with the bifunctional,
macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), and labeled
with the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic
activity. Upon administration of actinium Ac 225-DOTA-h11B6 JNJ-69086420, the monoclonal
antibody moiety of JNJ-69086420 targets and binds to hK2, thereby delivering a cytotoxic
dose of alpha radiation to hK2-expressing tumor cells. hK2 is overexpressed on a variety
of cancer cells.;
Molecule name : JNJ-69086420; JNJ 69086420;
NCI Metathesaurus CUI : CL1642669;
Origin ID : C176627;
UMLS CUI : C5447334;
Semantic type(s)
- concept_is_in_subset
- has_target
