NCIt definition : A monoclonal antibody directed against the negative immunoregulatory human cell surface
receptor CD96 (Tactile; T cell activation increased late expression), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, nelistotug
targets, binds to and inhibits CD96 expressed primarily on T-cells and natural killer
(NK) cells, thereby preventing its downstream signaling pathways. This may abrogate
CD96-mediated inhibition of T-cell and NK cell effector function and may restore immune
function and anti-tumor immune responses through the activation of T-cells and NKs.
This may kill and inhibit growth of tumor cells. CD96, a type I transmembrane glycoprotein
of the immunoglobulin superfamily and immunological checkpoint for CD8 T-cells and
NK cells, negatively regulates T-cell and NK cell activation and is overexpressed
in a variety of cancer settings.;
Semantic type(s)