NCIt definition : A bispecific monoclonal antibody against both the tumor-associated antigen (TAA) human
mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303) and the co-stimulatory T-cell-specific
surface glycoprotein CD28, with potential antineoplastic and immunostimulating activities.
Upon administration, anti-MUC16/CD28 bispecific antibody REGN5668 binds to both CD28
on T-cells and MUC16-expressing tumor cells, which cross-links the T-cells to the
tumor cells. This may result in a potent cytotoxic T-lymphocyte (CTL) response against
the MUC16-expressing tumor cells. MUC16, a member of the mucin family of glycoproteins,
is overexpressed by several epithelial cancers, including ovarian cancer.;
Semantic type(s)