Preferred Label : DLL3/CD3e Tri-specific T-cell Activating Construct HPN328;
NCIt synonyms : DLL3/CD3e TriTAC HPN328; Anti-DLL3 T-cell Engager HPN328; TriTAC HPN328;
NCIt definition : A recombinant antibody derivative composed of tri-specific T-cell activating construct
(TriTAC) containing three humanized antibody derived binding domains: a N-terminal
single chain Fv (scFv) that binds to the epsilon domain of CD3 antigen (CD3e) of the
T cell receptor (TCR), a middle single domain antibody (sdAb) that binds to human
serum albumin (HSA) to extend the half-life, and a C-terminal sdAb that binds to human
tumor-associated antigen (TAA) delta-like protein 3 (DLL3; delta like canonical Notch
ligand 3), with potential immunostimulating and antineoplastic activities. Upon administration,
DLL3/CD3e TriTAC HPN328 targets and binds to DLL3 on tumor cells and CD3e on cytotoxic
T-lymphocytes (CTLs), thereby bringing DLL3-expressing tumor cells and CTLs together,
which results in the CTL-mediated cell death of DLL3-expressing tumor cells. The albumin-binding
domain targets and binds to serum albumin, thereby extending the serum half-life of
HPN328. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell
types while its expression is limited in normal tissues. It plays a key role in embryonic
development and in tumor initiation and proliferation.;
Molecule name : HPN-328; HPN 328;
NCI Metathesaurus CUI : CL1413140;
Origin ID : C175947;
UMLS CUI : C5446875;
Semantic type(s)
- concept_is_in_subset
- has_target
