NCIt definition : An orally bioavailable inhibitor of heat shock protein 90 (Hsp90), with potential
antineoplastic activity. Upon oral administration, Hsp90 inhibitor MPT0B640 specifically
blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation
of oncogenic signaling proteins involved in tumor cell proliferation and survival.
This may lead to the inhibition of tumor cell proliferation. Hsp90, a chaperone complex
protein upregulated in a variety of tumor cell types, regulates the folding and degradation
of many oncogenic signaling proteins.;
Semantic type(s)